' 
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.4
USERS' SCORE
Good
Based on 4 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg
20833%
Iron (from Brown Rice Chelate)
22 mg
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+
Top Medical Research Studies
8
Folic Acid reduces IBS-related pain
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production.
Study shows promising treatment effects
We investigated the effects of Folic Acid (FA) on chronic visceral pain linked to Irritable Bowel Syndrome (IBS). Chronic visceral hyperalgesia (pain sensitivity) was induced in rats through neonatal colonic inflammation, enabling us to examine how FA might alleviate this condition.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Read More
4
Iron Supplementation and Gut Microbiota
The Impact of Low-Level Iron Supplements on the Faecal Microbiota of Irritable Bowel Syndrome and Healthy Donors Using In Vitro Batch Cultures.
Focuses on IBS and microbiota
We explored how low-level iron supplementation impacts the gut microbiota in individuals with Irritable Bowel Syndrome (IBS) and in healthy donors. To do this, we conducted anaerobic, pH-controlled in vitro batch cultures using fecal samples from both groups, supplemented with various forms of iron, including ferrous sulphate, nanoparticulate iron, and pea ferritin.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
Read More
9.5
Celiac disease linked to IBS symptoms
Celiac Disease Initially Misdiagnosed as Irritable Bowel Syndrome: Case Report.
Significance in understanding IBS treatment
We explored a fascinating case of a 30-year-old patient who was initially diagnosed with irritable bowel syndrome (IBS) due to vague abdominal symptoms. However, this diagnosis was later challenged when he presented with iron deficiency anemia in our clinic.
Upon further investigation for the cause of his anemia, we discovered he actually had celiac disease, confirmed by positive serological tests and a small bowel biopsy. After starting a gluten-free diet and taking iron supplements, we observed a complete improvement in both his abdominal symptoms and his anemia.
This case brings to light the complexities of diagnosing gastrointestinal issues. It emphasizes the need for routine screening for celiac disease in patients who may present with symptoms that could easily be misattributed to IBS—especially when iron deficiency anemia is involved.
Upon further investigation for the cause of his anemia, we discovered he actually had celiac disease, confirmed by positive serological tests and a small bowel biopsy. After starting a gluten-free diet and taking iron supplements, we observed a complete improvement in both his abdominal symptoms and his anemia.
This case brings to light the complexities of diagnosing gastrointestinal issues. It emphasizes the need for routine screening for celiac disease in patients who may present with symptoms that could easily be misattributed to IBS—especially when iron deficiency anemia is involved.
Read More
Most Useful Reviews
9.5
Calms digestive issues
This iron supplement is remarkable! I have irritable bowel syndrome and most iron products upset my stomach, but this one actually improves and soothes it. With added digestive enzymes, my digestion has significantly improved alongside my low iron levels.
Read More
10
Perfect for IBS
This is one of Garden of Life's best products. As a vegan, I take it during menstruation to combat iron deficiency, and it contains added vitamins and digestive enzymes which help with my irritable bowel syndrome. I always keep it at home as it suits my digestion perfectly.
Read More
8.8
Improved menstrual symptoms
My iron deficiency anaemia was initially troublesome. I believed I was weak, but after researching iron constipation, I started taking the powder. It has improved my menstrual syndrome significantly—over 80%! Previously, my cycle required me to starve for a week, but now I only need to manage it for a couple of days. No more constipation or unpleasant odours, and I only take one capsule daily.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.4
9.5
Celiac disease linked to IBS symptoms
Celiac Disease Initially Misdiagnosed as Irritable Bowel Syndrome: Case Report.
Significance in understanding IBS treatment
We explored a fascinating case of a 30-year-old patient who was initially diagnosed with irritable bowel syndrome (IBS) due to vague abdominal symptoms. However, this diagnosis was later challenged when he presented with iron deficiency anemia in our clinic.
Upon further investigation for the cause of his anemia, we discovered he actually had celiac disease, confirmed by positive serological tests and a small bowel biopsy. After starting a gluten-free diet and taking iron supplements, we observed a complete improvement in both his abdominal symptoms and his anemia.
This case brings to light the complexities of diagnosing gastrointestinal issues. It emphasizes the need for routine screening for celiac disease in patients who may present with symptoms that could easily be misattributed to IBS—especially when iron deficiency anemia is involved.
Upon further investigation for the cause of his anemia, we discovered he actually had celiac disease, confirmed by positive serological tests and a small bowel biopsy. After starting a gluten-free diet and taking iron supplements, we observed a complete improvement in both his abdominal symptoms and his anemia.
This case brings to light the complexities of diagnosing gastrointestinal issues. It emphasizes the need for routine screening for celiac disease in patients who may present with symptoms that could easily be misattributed to IBS—especially when iron deficiency anemia is involved.
Read More
8
Folic Acid reduces IBS-related pain
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production.
Study shows promising treatment effects
We investigated the effects of Folic Acid (FA) on chronic visceral pain linked to Irritable Bowel Syndrome (IBS). Chronic visceral hyperalgesia (pain sensitivity) was induced in rats through neonatal colonic inflammation, enabling us to examine how FA might alleviate this condition.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Read More
8
Dietary guidance aids IBS management
Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome.
Limited single-vitamin isolation effect
We examined how dietary guidance affects irritable bowel syndrome (IBS) symptoms and quality of life, particularly focusing on vitamin B12 intake. Our study involved 46 patients diagnosed with IBS based on established criteria, with 17 completing the entire program.
Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.
Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.
In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.
Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.
Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.
In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.
Read More
4
Iron Supplementation and Gut Microbiota
The Impact of Low-Level Iron Supplements on the Faecal Microbiota of Irritable Bowel Syndrome and Healthy Donors Using In Vitro Batch Cultures.
Focuses on IBS and microbiota
We explored how low-level iron supplementation impacts the gut microbiota in individuals with Irritable Bowel Syndrome (IBS) and in healthy donors. To do this, we conducted anaerobic, pH-controlled in vitro batch cultures using fecal samples from both groups, supplemented with various forms of iron, including ferrous sulphate, nanoparticulate iron, and pea ferritin.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.7
10
Perfect for IBS
This is one of Garden of Life's best products. As a vegan, I take it during menstruation to combat iron deficiency, and it contains added vitamins and digestive enzymes which help with my irritable bowel syndrome. I always keep it at home as it suits my digestion perfectly.
9.5
Calms digestive issues
This iron supplement is remarkable! I have irritable bowel syndrome and most iron products upset my stomach, but this one actually improves and soothes it. With added digestive enzymes, my digestion has significantly improved alongside my low iron levels.
8.8
Improved menstrual symptoms
My iron deficiency anaemia was initially troublesome. I believed I was weak, but after researching iron constipation, I started taking the powder. It has improved my menstrual syndrome significantly—over 80%! Previously, my cycle required me to starve for a week, but now I only need to manage it for a couple of days. No more constipation or unpleasant odours, and I only take one capsule daily.
Read More
8.8
Supports digestion well
This product is fantastic! With a sensitive digestive system, I tolerate it well and feel it’s aiding my absorption. It has been beneficial for my premenstrual syndrome as well.
